Chicken Bubble Biscuit Bake Casserole

This Chicken Bubble Biscuit Bake Casserole is an easy, comforting dinner made with tender chicken, creamy sauce, vegetables, and golden, fluffy biscuit pieces all baked together under a blanket of melted cheese. It’s a cozy, family-friendly meal that comes together with minimal prep and delivers maximum comfort.

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Prep Time 10

Cook Time 30

Total Time 40

Servings: 6 servings

Course: Casserole, Dinner

Cuisine: American, Comfort Food

Calories: 480

Ingredients Method Notes

Ingredients

Main Ingredients

2 cups Cooked chicken Shredded or diced; rotisserie works great
10.5 oz Cream of chicken soup Or cream of mushroom
0.5 cup Sour cream Or plain Greek yogurt
0.5 cup Milk
1 cup Frozen mixed vegetables Peas, carrots, corn, and green beans
1 tsp Garlic powder
0.5 tsp Onion powder
Salt and pepper To taste
16 oz Refrigerated biscuit dough Cut into quarters
1 cup Shredded cheddar cheese Or mozzarella
1 tbsp Melted butter Optional, for brushing

Method

Preheat oven to 350°F (175°C). Lightly grease a 9x13-inch baking dish.
In a large mixing bowl, combine the cooked chicken, cream of chicken soup, sour cream, milk, frozen vegetables, garlic powder, onion powder, salt, and pepper. Stir until smooth and well blended.
Fold the quartered biscuit dough pieces into the mixture until evenly coated.
Pour the mixture into the prepared baking dish and spread it evenly. Sprinkle shredded cheese over the top.
Cover the dish with foil and bake for 20 minutes. Remove the foil and bake an additional 10–15 minutes, or until the biscuits are puffed, golden brown, and cooked through.
Brush with melted butter if desired. Let cool slightly before serving.

Notes

For extra flavor, try adding a pinch of smoked paprika or Italian seasoning. Use rotisserie chicken for convenience. Substitute Greek yogurt for a lighter option. This casserole reheats well and is perfect for meal prep.