Paula Deen Chicken Casserole

Paula Deen Chicken Casserole is a comforting Southern classic packed with tender chicken, creamy cheese sauce, and perfectly cooked pasta. It's warm, hearty, and easy to make — perfect for family dinners or potlucks.

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Prep Time 15

Cook Time 25

Total Time 40

Servings: 6 servings

Course: Dinner, Main Course

Cuisine: American, Southern

Calories: 480

Ingredients Method Notes

Ingredients

2 cups Cooked chicken chopped into bite-sized pieces
4 cups Cooked pasta about 2 cups uncooked
3 tablespoons Unsalted butter
1 small Onion finely chopped
2 cloves Garlic minced
2 tablespoons All-purpose flour
0.5 cup Sour cream
1 cup Milk
3.5 cups Shredded cheese divided
0.5 teaspoon Red pepper flakes
Salt & black pepper to taste

Method

1. Preheat the Oven: Set to 350°F (175°C). Lightly grease a 9x13-inch baking dish.
2. Cook the Aromatics: In a large skillet, melt butter over medium heat. Add onion and sauté until soft, about 3 minutes. Stir in garlic and cook for 30 seconds.
3. Make the Roux: Sprinkle flour over the onion mixture and stir for 1 minute to remove the raw flour taste.
4. Create the Sauce: Slowly whisk in milk until smooth. Stir in sour cream, 3 cups shredded cheese, red pepper flakes, salt, and pepper. Cook until the cheese melts and the sauce thickens.
5. Combine: In a large bowl, mix cooked pasta, chicken, and the cheese sauce until evenly coated.
6. Assemble: Spread mixture into the prepared baking dish and sprinkle remaining cheese over the top.
7. Bake: Cook uncovered for 20–25 minutes, until bubbly and golden brown on top.
8. Serve: Let the casserole rest for 5 minutes before serving for easier scooping. Enjoy warm!

Notes

This recipe is highly customizable — try adding chopped broccoli, peas, or diced bell peppers for extra flavor and color. For a little crunch, top with buttery breadcrumbs or crushed Ritz crackers before baking.